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Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology
Southeast Asia is an epicenter of multidrug-resistant Plasmodium falciparum strains. Selective pressures on the subcontinent have recurrently produced several allelic variants of parasite drug resistance genes, including the P. falciparum chloroquine resistance transporter (pfcrt). Despite significa...
Zapisane w:
Wydane w: | PLoS Pathog |
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Główni autorzy: | , , , , , , , , , , , , , , |
Format: | Artigo |
Język: | Inglês |
Wydane: |
Public Library of Science
2016
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5104409/ https://ncbi.nlm.nih.gov/pubmed/27832198 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005976 |
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