Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

Southeast Asia is an epicenter of multidrug-resistant Plasmodium falciparum strains. Selective pressures on the subcontinent have recurrently produced several allelic variants of parasite drug resistance genes, including the P. falciparum chloroquine resistance transporter (pfcrt). Despite significa...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:PLoS Pathog
मुख्य लेखकों: Gabryszewski, Stanislaw J., Dhingra, Satish K., Combrinck, Jill M., Lewis, Ian A., Callaghan, Paul S., Hassett, Matthew R., Siriwardana, Amila, Henrich, Philipp P., Lee, Andrew H., Gnädig, Nina F., Musset, Lise, Llinás, Manuel, Egan, Timothy J., Roepe, Paul D., Fidock, David A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2016
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104409/
https://ncbi.nlm.nih.gov/pubmed/27832198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005976
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