Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

Southeast Asia is an epicenter of multidrug-resistant Plasmodium falciparum strains. Selective pressures on the subcontinent have recurrently produced several allelic variants of parasite drug resistance genes, including the P. falciparum chloroquine resistance transporter (pfcrt). Despite significa...

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Pubblicato in:PLoS Pathog
Autori principali: Gabryszewski, Stanislaw J., Dhingra, Satish K., Combrinck, Jill M., Lewis, Ian A., Callaghan, Paul S., Hassett, Matthew R., Siriwardana, Amila, Henrich, Philipp P., Lee, Andrew H., Gnädig, Nina F., Musset, Lise, Llinás, Manuel, Egan, Timothy J., Roepe, Paul D., Fidock, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104409/
https://ncbi.nlm.nih.gov/pubmed/27832198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005976
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