Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

Southeast Asia is an epicenter of multidrug-resistant Plasmodium falciparum strains. Selective pressures on the subcontinent have recurrently produced several allelic variants of parasite drug resistance genes, including the P. falciparum chloroquine resistance transporter (pfcrt). Despite significa...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS Pathog
Päätekijät: Gabryszewski, Stanislaw J., Dhingra, Satish K., Combrinck, Jill M., Lewis, Ian A., Callaghan, Paul S., Hassett, Matthew R., Siriwardana, Amila, Henrich, Philipp P., Lee, Andrew H., Gnädig, Nina F., Musset, Lise, Llinás, Manuel, Egan, Timothy J., Roepe, Paul D., Fidock, David A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2016
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104409/
https://ncbi.nlm.nih.gov/pubmed/27832198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005976
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