Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease

Sarcopenia is associated with increased morbidity and mortality in chronic kidney disease (CKD). Pathogenic mechanism of skeletal muscle loss in CKD, which is defined as uremic sarcopenia, remains unclear. We found that causative pathological mechanism of uremic sarcopenia is metabolic alterations b...

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Publicado en:Sci Rep
Main Authors: Sato, Emiko, Mori, Takefumi, Mishima, Eikan, Suzuki, Arisa, Sugawara, Sanae, Kurasawa, Naho, Saigusa, Daisuke, Miura, Daisuke, Morikawa-Ichinose, Tomomi, Saito, Ritsumi, Oba-Yabana, Ikuko, Oe, Yuji, Kisu, Kiyomi, Naganuma, Eri, Koizumi, Kenji, Mokudai, Takayuki, Niwano, Yoshimi, Kudo, Tai, Suzuki, Chitose, Takahashi, Nobuyuki, Sato, Hiroshi, Abe, Takaaki, Niwa, Toshimitsu, Ito, Sadayoshi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103201/
https://ncbi.nlm.nih.gov/pubmed/27830716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36618
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