Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease

Sarcopenia is associated with increased morbidity and mortality in chronic kidney disease (CKD). Pathogenic mechanism of skeletal muscle loss in CKD, which is defined as uremic sarcopenia, remains unclear. We found that causative pathological mechanism of uremic sarcopenia is metabolic alterations b...

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Publicado no:Sci Rep
Main Authors: Sato, Emiko, Mori, Takefumi, Mishima, Eikan, Suzuki, Arisa, Sugawara, Sanae, Kurasawa, Naho, Saigusa, Daisuke, Miura, Daisuke, Morikawa-Ichinose, Tomomi, Saito, Ritsumi, Oba-Yabana, Ikuko, Oe, Yuji, Kisu, Kiyomi, Naganuma, Eri, Koizumi, Kenji, Mokudai, Takayuki, Niwano, Yoshimi, Kudo, Tai, Suzuki, Chitose, Takahashi, Nobuyuki, Sato, Hiroshi, Abe, Takaaki, Niwa, Toshimitsu, Ito, Sadayoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103201/
https://ncbi.nlm.nih.gov/pubmed/27830716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36618
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