The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development

Ubiquitination is a crucial post-translational modification; however, the functions of ubiquitin-coding genes remain unclear. UBA52 encodes a fusion protein comprising ubiquitin at the N-terminus and ribosomal protein L40 (RPL40) at the C-terminus. Here we showed that Uba52-deficient mice die during...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kobayashi, Masanori, Oshima, Shigeru, Maeyashiki, Chiaki, Nibe, Yoichi, Otsubo, Kana, Matsuzawa, Yu, Nemoto, Yasuhiro, Nagaishi, Takashi, Okamoto, Ryuichi, Tsuchiya, Kiichiro, Nakamura, Tetsuya, Watanabe, Mamoru
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103194/
https://ncbi.nlm.nih.gov/pubmed/27829658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36780
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