Enantioselective Generation of Adjacent Stereocenters in a Copper‐Catalyzed Three‐Component Coupling of Imines, Allenes, and Diboranes

A highly enantio‐ and diastereoselective copper‐catalyzed three‐component coupling affords the first general synthesis of homoallylic amines bearing adjacent stereocenters from achiral starting materials. The method utilizes a commercially available NHC ligand and copper source, operates at ambient...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Yeung, Kay, Ruscoe, Rebecca E., Rae, James, Pulis, Alexander P., Procter, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5103189/
https://ncbi.nlm.nih.gov/pubmed/27539673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201606710
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