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Enantioselective, Copper(I)-Catalyzed Alkynylation of Oxocarbenium Ions to Set Diaryl Tetrasubstituted Stereocenters()

We have developed an enantioselective, copper(I)-catalyzed addition of terminal alkynes to isochroman ketals to set diaryl, tetrasubstituted stereocenters. The success of this reaction relies on identification of a Cu/PyBox catalyst capable of distinguishing the faces of the diaryl-substituted oxoca...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Dasgupta, Srimoyee, Rivas, Thomas, Watson, Mary P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819992/
https://ncbi.nlm.nih.gov/pubmed/26403641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201507373
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