N-acetylaspartate Supports the Energetic Demands of Developmental Myelination via Oligodendroglial Aspartoacylase

Breakdown of neuro-glial N-acetyl-aspartate (NAA) metabolism results in the failure of developmental myelination, manifest in the congenital pediatric leukodystrophy Canavan disease caused by mutations to the sole NAA catabolizing enzyme aspartoacylase. Canavan disease is a major point of focus for...

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Vydáno v:Neurobiol Dis
Hlavní autoři: Francis, Jeremy S., Wojtas, Ireneusz, Markov, Vladimir, Gray, Steven J., McCown, Thomas J., Samulski, R. Jude, Bilaniuk, Larissa T., Wang, Dah-Jyuu, De Vivo, Darryl C., Janson, Christopher G., Leone, Paola
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5102763/
https://ncbi.nlm.nih.gov/pubmed/27717881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.10.001
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