A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca(2+) dysregulation and decrease in ATP levels

Small fiber neuropathy is a painful sensory nervous system disorder characterized by damage to unmyelinated C- and thinly myelinated Aδ- nerve fibers, clinically manifested by burning pain in the distal extremities and dysautonomia. The clinical onset in adulthood suggests a time-dependent process....

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Bibliographic Details
Published in:Mol Pain
Main Authors: Rolyan, Harshvardhan, Liu, Shujun, Hoeijmakers, Janneke GJ, Faber, Catharina G, Merkies, Ingemar SJ, Lauria, Giuseppe, Black, Joel A, Waxman, Stephen G
Format: Artigo
Language:Inglês
Published: SAGE Publications 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5102167/
https://ncbi.nlm.nih.gov/pubmed/27821467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806916674472
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