The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes

In monocytic cells, Toll-like receptor 4 (TLR4)- and TLR2-induced reactive oxygen species (ROS) cause oxidative stress and inflammatory response; however, the mechanism is not well understood. The present study investigated the role of interleukin-1 receptor-associated kinase (IRAK), extracellular s...

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Publicat a:Cell Mol Immunol
Autors principals: Singh, Ankita, Singh, Vishal, Tiwari, Rajiv L., Chandra, Tulika, Kumar, Ashutosh, Dikshit, Madhu, Barthwal, Manoj K.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101443/
https://ncbi.nlm.nih.gov/pubmed/26320741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2015.62
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