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Progranulin Controls Sepsis via C/EBPα-regulated Il10 Transcription and Ubiquitin Ligase-Proteasome-mediated Protein Degradation
Progranulin (PGRN) is a widely expressed, pleiotropic protein that is involved in diverse biological processes including cellular proliferation, neuron development and wound healing. However, the role of PGRN in the regulation of pathogen-induced systemic inflammation and the mechanisms involved hav...
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| Published in: | J Immunol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5101149/ https://ncbi.nlm.nih.gov/pubmed/27619993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600862 |
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