Aging amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion

Inflammation and zinc dyshomeostasis are two common hallmarks of aging. A major zinc transporter ZIP14 (slc39a14) is upregulated by proinflammatory stimuli, e.g. interleukin-6. We have evaluated the influence of age on the Zip14 KO phenotype using wild-type (WT) and Zip14 knockout (KO) mice. Aging p...

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Publicat a:Exp Gerontol
Autors principals: Aydemir, Tolunay Beker, Troche, Catalina, Kim, Jinhee, Kim, Min-Hyun, Teran, Oriana Y., Leeuwenburgh, Christiaan, Cousins, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5101137/
https://ncbi.nlm.nih.gov/pubmed/27647172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2016.09.013
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