A phenome-wide association study of a lipoprotein-associated phospholipase A(2) loss-of-function variant in 90 000 Chinese adults

Background: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has been implicated in development of atherosclerosis; however, recent randomized trials of Lp-PLA(2) inhibition reported no beneficial effects on vascular diseases. In East Asians, a loss-of-function variant in the PLA2G7 gene can be...

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Detalhes bibliográficos
Publicado no:Int J Epidemiol
Main Authors: Millwood, Iona Y, Bennett, Derrick A, Walters, Robin G, Clarke, Robert, Waterworth, Dawn, Johnson, Toby, Chen, Yiping, Yang, Ling, Guo, Yu, Bian, Zheng, Hacker, Alex, Yeo, Astrid, Parish, Sarah, Hill, Michael R, Chissoe, Stephanie, Peto, Richard, Cardon, Lon, Collins, Rory, Li, Liming, Chen, Zhengming
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Mendelian Randomization
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100610/
https://ncbi.nlm.nih.gov/pubmed/27301456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyw087
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