A phenome-wide association study of a lipoprotein-associated phospholipase A(2) loss-of-function variant in 90 000 Chinese adults

Background: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has been implicated in development of atherosclerosis; however, recent randomized trials of Lp-PLA(2) inhibition reported no beneficial effects on vascular diseases. In East Asians, a loss-of-function variant in the PLA2G7 gene can be...

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Detalles Bibliográficos
Publicado en:Int J Epidemiol
Main Authors: Millwood, Iona Y, Bennett, Derrick A, Walters, Robin G, Clarke, Robert, Waterworth, Dawn, Johnson, Toby, Chen, Yiping, Yang, Ling, Guo, Yu, Bian, Zheng, Hacker, Alex, Yeo, Astrid, Parish, Sarah, Hill, Michael R, Chissoe, Stephanie, Peto, Richard, Cardon, Lon, Collins, Rory, Li, Liming, Chen, Zhengming
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
Assuntos:
Mendelian Randomization
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100610/
https://ncbi.nlm.nih.gov/pubmed/27301456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyw087
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