A phenome-wide association study of a lipoprotein-associated phospholipase A(2) loss-of-function variant in 90 000 Chinese adults

Background: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has been implicated in development of atherosclerosis; however, recent randomized trials of Lp-PLA(2) inhibition reported no beneficial effects on vascular diseases. In East Asians, a loss-of-function variant in the PLA2G7 gene can be...

詳細記述

保存先:
書誌詳細
出版年:Int J Epidemiol
主要な著者: Millwood, Iona Y, Bennett, Derrick A, Walters, Robin G, Clarke, Robert, Waterworth, Dawn, Johnson, Toby, Chen, Yiping, Yang, Ling, Guo, Yu, Bian, Zheng, Hacker, Alex, Yeo, Astrid, Parish, Sarah, Hill, Michael R, Chissoe, Stephanie, Peto, Richard, Cardon, Lon, Collins, Rory, Li, Liming, Chen, Zhengming
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2016
主題:
Mendelian Randomization
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100610/
https://ncbi.nlm.nih.gov/pubmed/27301456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ije/dyw087
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