Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs

Acidic mammalian chitinase (AMCase) is implicated in asthma, allergic inflammation, and food processing. Little is known about genetic and evolutional regulation of chitinolytic activity of AMCase. Here, we relate human AMCase polymorphisms to the mouse AMCase, and show that the highly active varian...

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Bibliographic Details
Published in:Mol Biol Evol
Main Authors: Okawa, Kazuaki, Ohno, Misa, Kashimura, Akinori, Kimura, Masahiro, Kobayashi, Yuki, Sakaguchi, Masayoshi, Sugahara, Yasusato, Kamaya, Minori, Kino, Yoshihiro, Bauer, Peter O., Oyama, Fumitaka
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
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Discoveries
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100053/
https://ncbi.nlm.nih.gov/pubmed/27702777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msw198
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