Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs

Acidic mammalian chitinase (AMCase) is implicated in asthma, allergic inflammation, and food processing. Little is known about genetic and evolutional regulation of chitinolytic activity of AMCase. Here, we relate human AMCase polymorphisms to the mouse AMCase, and show that the highly active varian...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Main Authors: Okawa, Kazuaki, Ohno, Misa, Kashimura, Akinori, Kimura, Masahiro, Kobayashi, Yuki, Sakaguchi, Masayoshi, Sugahara, Yasusato, Kamaya, Minori, Kino, Yoshihiro, Bauer, Peter O., Oyama, Fumitaka
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Discoveries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100053/
https://ncbi.nlm.nih.gov/pubmed/27702777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msw198
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