DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Aβ-induced neuronal damage via the Akt/JNK signaling pathway

AIM: 1,1′-([1,1′-Biphenyl]-4,4′-diyl)bis(3-(piperidin-1-yl)propan-1-one)dihydrochloride (DL0410) is a novel synthetic dual acetylcholinesterase (AChE)/butyrocholinesterase (BuChE) inhibitor, which has shown a potential therapeutic effect on Alzheimer's disease (AD). In this study we examined wh...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Pharmacol Sin
Auteurs principaux: Zhou, Dan, Zhou, Wei, Song, Jun-ke, Feng, Zhang-ying, Yang, Ran-yao, Wu, Song, Wang, Lin, Liu, Ai-lin, Du, Guan-hua
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099417/
https://ncbi.nlm.nih.gov/pubmed/27498773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.87
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