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Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication
The Rif1 protein is a negative regulator of DNA replication initiation in eukaryotes. Here we show that budding yeast Rif1 inhibits DNA replication initiation at the rDNA locus. Absence of Rif1, or disruption of its interaction with PP1/Glc7 phosphatase, leads to more intensive rDNA replication. The...
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| Izdano u: | PLoS Genet |
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| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5098799/ https://ncbi.nlm.nih.gov/pubmed/27820830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006414 |
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