Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication

The Rif1 protein is a negative regulator of DNA replication initiation in eukaryotes. Here we show that budding yeast Rif1 inhibits DNA replication initiation at the rDNA locus. Absence of Rif1, or disruption of its interaction with PP1/Glc7 phosphatase, leads to more intensive rDNA replication. The...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Genet
Prif Awduron: Shyian, Maksym, Mattarocci, Stefano, Albert, Benjamin, Hafner, Lukas, Lezaja, Aleksandra, Costanzo, Michael, Boone, Charlie, Shore, David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098799/
https://ncbi.nlm.nih.gov/pubmed/27820830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006414
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