Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication

The Rif1 protein is a negative regulator of DNA replication initiation in eukaryotes. Here we show that budding yeast Rif1 inhibits DNA replication initiation at the rDNA locus. Absence of Rif1, or disruption of its interaction with PP1/Glc7 phosphatase, leads to more intensive rDNA replication. The...

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Pubblicato in:PLoS Genet
Autori principali: Shyian, Maksym, Mattarocci, Stefano, Albert, Benjamin, Hafner, Lukas, Lezaja, Aleksandra, Costanzo, Michael, Boone, Charlie, Shore, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098799/
https://ncbi.nlm.nih.gov/pubmed/27820830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006414
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