Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication

The Rif1 protein is a negative regulator of DNA replication initiation in eukaryotes. Here we show that budding yeast Rif1 inhibits DNA replication initiation at the rDNA locus. Absence of Rif1, or disruption of its interaction with PP1/Glc7 phosphatase, leads to more intensive rDNA replication. The...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Shyian, Maksym, Mattarocci, Stefano, Albert, Benjamin, Hafner, Lukas, Lezaja, Aleksandra, Costanzo, Michael, Boone, Charlie, Shore, David
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098799/
https://ncbi.nlm.nih.gov/pubmed/27820830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006414
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