Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication

The Rif1 protein is a negative regulator of DNA replication initiation in eukaryotes. Here we show that budding yeast Rif1 inhibits DNA replication initiation at the rDNA locus. Absence of Rif1, or disruption of its interaction with PP1/Glc7 phosphatase, leads to more intensive rDNA replication. The...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Genet
Egile Nagusiak: Shyian, Maksym, Mattarocci, Stefano, Albert, Benjamin, Hafner, Lukas, Lezaja, Aleksandra, Costanzo, Michael, Boone, Charlie, Shore, David
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2016
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098799/
https://ncbi.nlm.nih.gov/pubmed/27820830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006414
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