Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain

Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a severe dose- and therapy-limiting side effect of widely used cytostatics that is particularly difficult to treat. Here, we report increased expression of the cytochrome-P(450)-epoxygenase CYP2J6 and increased concentrations of its linolei...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Sisignano, Marco, Angioni, Carlo, Park, Chul-Kyu, Meyer Dos Santos, Sascha, Jordan, Holger, Kuzikov, Maria, Liu, Di, Zinn, Sebastian, Hohman, Stephan W., Schreiber, Yannick, Zimmer, Béla, Schmidt, Mike, Lu, Ruirui, Suo, Jing, Zhang, Dong-Dong, Schäfer, Stephan M. G., Hofmann, Martine, Yekkirala, Ajay S., de Bruin, Natasja, Parnham, Michael J., Woolf, Clifford J., Ji, Ru-Rong, Scholich, Klaus, Geisslinger, Gerd
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098623/
https://ncbi.nlm.nih.gov/pubmed/27791151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613246113
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