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Mg(2+) Shifts Ligand-Mediated Folding of a Riboswitch from Induced-Fit to Conformational Selection
Bacterial riboswitches couple small-molecule ligand binding to RNA conformational changes that widely regulate gene expression, rendering them potential targets for antibiotic intervention. Despite structural insights, the ligand mediated folding mechanisms of riboswitches are still poorly understoo...
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| Izdano u: | J Am Chem Soc |
|---|---|
| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5098500/ https://ncbi.nlm.nih.gov/pubmed/26471732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b09740 |
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