Utility of immunodeficient mouse models for characterizing the preclinical pharmacokinetics of immunogenic antibody therapeutics

Prior to clinical studies, the pharmacokinetics (PK) of antibody-based therapeutics are characterized in preclinical species; however, those species can elicit immunogenic responses that can lead to an inaccurate estimation of PK parameters. Immunodeficient (SCID) transgenic hFcRn and C57BL/6 mice w...

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Detaylı Bibliyografya
Yayımlandı:MAbs
Asıl Yazarlar: Myzithras, Maria, Bigwarfe, Tammy, Li, Hua, Waltz, Erica, Ahlberg, Jennifer, Giragossian, Craig, Roberts, Simon
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2016
Konular:
Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098443/
https://ncbi.nlm.nih.gov/pubmed/27598372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1229721
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