Pharmacokinetics, immunogenicity and bioactivity of the therapeutic antibody catumaxomab intraperitoneally administered to cancer patients

AIMS: Catumaxomab is the first EMEA approved trifunctional anti-EpCAM×anti-CD3 antibody for the treatment of cancer patients with malignant ascites. A phase II pharmacokinetic study was conducted to determine local and systemic antibody concentrations and anti-drug antibody (ADA) development. METHOD...

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Autori principali: Ruf, Peter, Kluge, Michael, Jäger, Michael, Burges, Alexander, Volovat, Constantin, Heiss, Markus Maria, Hess, Jürgen, Wimberger, Pauline, Brandt, Birgit, Lindhofer, Horst
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2010
Soggetti:
Pharmacodynamics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878603/
https://ncbi.nlm.nih.gov/pubmed/20565453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03635.x
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