Simultaneous monitoring of oxidation, deamidation, isomerization, and glycosylation of monoclonal antibodies by liquid chromatography-mass spectrometry method with ultrafast tryptic digestion

Monoclonal antibodies are subjected to a wide variety of post-translational modifications (PTMs) that cause structural heterogeneity. Characterization and control of these modifications or quality attributes are critical to ensure antibody quality and to define any potential effects on the ultimate...

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Vydáno v:MAbs
Hlavní autoři: Wang, Yi, Li, Xiaojuan, Liu, Yan-Hui, Richardson, Daisy, Li, Huijuan, Shameem, Mohammed, Yang, Xiaoyu
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098434/
https://ncbi.nlm.nih.gov/pubmed/27598507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1226715
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