Selective inhibition by a synthetic hirudin peptide of fibrin-dependent thrombosis in baboons.

To determine the importance of the thrombin substrate recognition exosite for fibrinogen binding in the formation of both arterial and venous thrombi, we evaluated the antithrombotic effects of the tyrosine-sulfated dodecapeptide from residues 53-64 of hirudin (H peptide) in a nonhuman primate model...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Cadroy, Y, Maraganore, J M, Hanson, S R, Harker, L A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50980/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1996320/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.4.1177
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