Inhibition of Interleukin-1β Decreases Aneurysm Formation and Progression in a Novel Model of Thoracic Aortic Aneurysms

BACKGROUND: Thoracic aortic aneurysms (TAAs) are common, but experimental TAA models are limited and the role of interleukin-1β (IL-1β) is undetermined. METHODS AND RESULTS: IL-1β protein was measured in human TAAs and control aortas, and IL-1β protein was increased ≈20-fold in human TAAs. To develo...

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Опубликовано в: :Circulation
Главные авторы: Johnston, William F., Salmon, Morgan, Pope, Nicolas H., Meher, Akshaya, Su, Gang, Stone, Matthew L., Lu, Guanyi, Owens, Gary K., Upchurch, Gilbert R., Ailawadi, Gorav
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097450/
https://ncbi.nlm.nih.gov/pubmed/25200056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.006800
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