The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase

Biofilms play a major role in Staphylococcus aureus pathogenicity but respond poorly to antibiotics. Here, we show that the antifungal caspofungin improves the activity of fluoroquinolones (moxifloxacin, delafloxacin) against S. aureus biofilms grown in vitro (96-well plates or catheters) and in viv...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Siala, Wafi, Kucharíková, Soňa, Braem, Annabel, Vleugels, Jef, Tulkens, Paul M, Mingeot-Leclercq, Marie-Paule, Van Dijck, Patrick, Van Bambeke, Françoise
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097165/
https://ncbi.nlm.nih.gov/pubmed/27808087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13286
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