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PEGylation of a High-Affinity Anti-(+)Methamphetamine Single Chain Antibody Fragment Extends Functional Half-Life by Reducing Clearance

PURPOSE: Methamphetamine (METH) abuse is a worldwide drug problem, yet no FDA-approved pharmacological treatments are available for METH abuse. Therefore, we produced an anti- METH single chain antibody fragment (scFv7F9Cys) as a pharmacological treatment for METH abuse. ScFv’s have a short half-lif...

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Udgivet i:Pharm Res
Main Authors: Reichard, Emily E., Nanaware-Kharade, Nisha, Gonzalez, Guillermo A., Thakkar, Shraddha, Owens, S. Michael, Peterson, Eric C.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5097033/
https://ncbi.nlm.nih.gov/pubmed/27620175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-016-2017-y
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