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Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering
Methamphetamine (METH) abuse is a worldwide threat, without any FDA approved medications. Anti-METH IgGs and single chain fragments (scFvs) have shown efficacy in preclinical studies. Here we report affinity enhancement of an anti-METH scFv for METH and its active metabolite amphetamine (AMP), throu...
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Main Authors: | , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Nature Publishing Group
2014
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4070344/ https://ncbi.nlm.nih.gov/pubmed/24419156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03673 |
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