Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering

Methamphetamine (METH) abuse is a worldwide threat, without any FDA approved medications. Anti-METH IgGs and single chain fragments (scFvs) have shown efficacy in preclinical studies. Here we report affinity enhancement of an anti-METH scFv for METH and its active metabolite amphetamine (AMP), throu...

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Main Authors: Thakkar, Shraddha, Nanaware-Kharade, Nisha, Celikel, Reha, Peterson, Eric C., Varughese, Kottayil I.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070344/
https://ncbi.nlm.nih.gov/pubmed/24419156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03673
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