Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy

Cancer cells express tumour-specific antigens derived via genetic and epigenetic alterations, which may be targeted by T-cell-mediated immune responses. However, cancer cells can avoid immune surveillance by suppressing immunity through activation of specific inhibitory signalling pathways, referred...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Lee, Ju Yeon, Lee, Hyun Tae, Shin, Woori, Chae, Jongseok, Choi, Jaemo, Kim, Sung Hyun, Lim, Heejin, Won Heo, Tae, Park, Kyeong Young, Lee, Yeon Ji, Ryu, Seong Eon, Son, Ji Young, Lee, Jee Un, Heo, Yong-Seok
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095608/
https://ncbi.nlm.nih.gov/pubmed/27796306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13354
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