Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy

Cancer cells express tumour-specific antigens derived via genetic and epigenetic alterations, which may be targeted by T-cell-mediated immune responses. However, cancer cells can avoid immune surveillance by suppressing immunity through activation of specific inhibitory signalling pathways, referred...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lee, Ju Yeon, Lee, Hyun Tae, Shin, Woori, Chae, Jongseok, Choi, Jaemo, Kim, Sung Hyun, Lim, Heejin, Won Heo, Tae, Park, Kyeong Young, Lee, Yeon Ji, Ryu, Seong Eon, Son, Ji Young, Lee, Jee Un, Heo, Yong-Seok
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095608/
https://ncbi.nlm.nih.gov/pubmed/27796306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13354
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