Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases

Bromodomain and extraterminal (BET) proteins are epigenetic “readers” that recognize acetylated histones and mark areas of the genome for transcription. BRD4, a BET family member protein, has been implicated in a number of types of cancer, and BET protein inhibitors (BETi) are efficacious in many pr...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Sahni, Jennifer M., Gayle, Sylvia S., Bonk, Kristen L. Weber, Vite, Leslie Cuellar, Yori, Jennifer L., Webb, Bryan, Ramos, Erika K., Seachrist, Darcie D., Landis, Melissa D., Chang, Jenny C., Bradner, James E., Keri, Ruth A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2016
Aiheet:
Molecular Bases of Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095428/
https://ncbi.nlm.nih.gov/pubmed/27650498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738666
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