Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases

Bromodomain and extraterminal (BET) proteins are epigenetic “readers” that recognize acetylated histones and mark areas of the genome for transcription. BRD4, a BET family member protein, has been implicated in a number of types of cancer, and BET protein inhibitors (BETi) are efficacious in many pr...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:J Biol Chem
Main Authors: Sahni, Jennifer M., Gayle, Sylvia S., Bonk, Kristen L. Weber, Vite, Leslie Cuellar, Yori, Jennifer L., Webb, Bryan, Ramos, Erika K., Seachrist, Darcie D., Landis, Melissa D., Chang, Jenny C., Bradner, James E., Keri, Ruth A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Molecular Bases of Disease
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095428/
https://ncbi.nlm.nih.gov/pubmed/27650498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738666
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla