Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases

Bromodomain and extraterminal (BET) proteins are epigenetic “readers” that recognize acetylated histones and mark areas of the genome for transcription. BRD4, a BET family member protein, has been implicated in a number of types of cancer, and BET protein inhibitors (BETi) are efficacious in many pr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sahni, Jennifer M., Gayle, Sylvia S., Bonk, Kristen L. Weber, Vite, Leslie Cuellar, Yori, Jennifer L., Webb, Bryan, Ramos, Erika K., Seachrist, Darcie D., Landis, Melissa D., Chang, Jenny C., Bradner, James E., Keri, Ruth A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095428/
https://ncbi.nlm.nih.gov/pubmed/27650498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738666
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