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Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases

Bromodomain and extraterminal (BET) proteins are epigenetic “readers” that recognize acetylated histones and mark areas of the genome for transcription. BRD4, a BET family member protein, has been implicated in a number of types of cancer, and BET protein inhibitors (BETi) are efficacious in many pr...

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書目詳細資料
發表在:J Biol Chem
Main Authors: Sahni, Jennifer M., Gayle, Sylvia S., Bonk, Kristen L. Weber, Vite, Leslie Cuellar, Yori, Jennifer L., Webb, Bryan, Ramos, Erika K., Seachrist, Darcie D., Landis, Melissa D., Chang, Jenny C., Bradner, James E., Keri, Ruth A.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095428/
https://ncbi.nlm.nih.gov/pubmed/27650498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738666
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