A Presenilin/Notch1 pathway regulated by miR-375, miR-30a, and miR-34a mediates glucotoxicity induced-pancreatic beta cell apoptosis

The presenilin-mediated Notch1 cleavage pathway plays a critical role in controlling pancreatic beta cell fate and survival. The aim of the present study was to investigate the role of Notch1 activation in glucotoxicity-induced beta cell impairment and the contributions of miR-375, miR-30a, and miR-...

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Vydáno v:Sci Rep
Hlavní autoři: Li, Yating, Zhang, Tao, Zhou, Yuncai, Sun, Yi, Cao, Yue, Chang, Xiaoai, Zhu, Yunxia, Han, Xiao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095347/
https://ncbi.nlm.nih.gov/pubmed/27804997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36136
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