T cell receptor recognition of CD1b presenting a mycobacterial glycolipid

CD1 proteins present microbial lipids to T cells. Germline-encoded mycolyl lipid-reactive (GEM) T cells with conserved αβ T cell receptors (TCRs) recognize CD1b presenting mycobacterial mycolates. As the molecular basis underpinning TCR recognition of CD1b remains unknown, here we determine the stru...

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Udgivet i:Nat Commun
Main Authors: Gras, Stephanie, Van Rhijn, Ildiko, Shahine, Adam, Cheng, Tan-Yun, Bhati, Mugdha, Tan, Li Lynn, Halim, Hanim, Tuttle, Kathryn D., Gapin, Laurent, Le Nours, Jérôme, Moody, D. Branch, Rossjohn, Jamie
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095289/
https://ncbi.nlm.nih.gov/pubmed/27807341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13257
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