Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the rapid and progressive degeneration of upper and lower motor neurons in the spinal cord, brain stem and motor cortex. The first gene linked to ALS was the gene encoding the free radical scavenging enzyme sup...

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Vydáno v:Front Neurosci
Hlavní autoři: McAlary, Luke, Aquilina, J. Andrew, Yerbury, Justin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095133/
https://ncbi.nlm.nih.gov/pubmed/27867347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2016.00499
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