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The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization

Bacterial growth depends crucially on metabolic fluxes, which are limited by the cell’s capacity to maintain metabolic enzymes. The necessary enzyme amount per unit flux is a major determinant of metabolic strategies both in evolution and bioengineering. It depends on enzyme parameters (such as k(ca...

詳細記述

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書誌詳細
出版年:PLoS Comput Biol
主要な著者: Noor, Elad, Flamholz, Avi, Bar-Even, Arren, Davidi, Dan, Milo, Ron, Liebermeister, Wolfram
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094713/
https://ncbi.nlm.nih.gov/pubmed/27812109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005167
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