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The Hidden Conundrum of Phosphoinositide Signaling in Cancer

Phosphoinositide 3-kinase (PI3K) generation of PI(3,4,5)P(3) from PI(4,5)P(2) and the subsequent activation of Akt and its downstream signaling cascades (e.g. mTORC1) dominates the landscape of phosphoinositide signaling axis in cancer research. However, PI(4,5)P(2) is breaking its boundary as merel...

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Detalhes bibliográficos
Publicado no:Trends Cancer
Main Authors: Thapa, Narendra, Tan, Xiaojun, Choi, Suyong, Lambert, Paul F., Rapraeger, Alan C., Anderson, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094282/
https://ncbi.nlm.nih.gov/pubmed/27819060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trecan.2016.05.009
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