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The Hidden Conundrum of Phosphoinositide Signaling in Cancer
Phosphoinositide 3-kinase (PI3K) generation of PI(3,4,5)P(3) from PI(4,5)P(2) and the subsequent activation of Akt and its downstream signaling cascades (e.g. mTORC1) dominates the landscape of phosphoinositide signaling axis in cancer research. However, PI(4,5)P(2) is breaking its boundary as merel...
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Publicado no: | Trends Cancer |
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Main Authors: | , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5094282/ https://ncbi.nlm.nih.gov/pubmed/27819060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trecan.2016.05.009 |
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