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Tumor Cell Recovery from Senescence Induced by Radiation with PARP Inhibition

Inhibitors of poly(ADP-ribose) polymerase (PARP) are clinically used as single-agent therapy for tumors with BRCA1 or BRCA2 mutations. One approach to expanding the use of PARP inhibitors to a wider range of tumors is to combine them with cytotoxic chemotherapy or radiotherapy. Preclinical studies i...

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Detalhes bibliográficos
Publicado no:Radiat Res
Main Authors: Gewirtz, David A., Alotaibi, Moureq, Yakovlev, Vasily A., Povirk, Lawrence F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094050/
https://ncbi.nlm.nih.gov/pubmed/27588595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR14437.1
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