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Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy

Studies of radiation interaction with tumor cells often focus on apoptosis as an end point; however, clinically relevant doses of radiation also promote autophagy and senescence. Moreover, functional p53 has frequently been implicated in contributing to radiation sensitivity through the facilitation...

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Publicat a:Radiat Res
Autors principals: Xu, Jingwen, Patel, Nipa H., Saleh, Tareq, Cudjoe, Emmanuel K., Alotaibi, Moureq, Wu, Yingliang, Lima, Santiago, Hawkridge, Adam M., Gewirtz, David A.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141768/
https://ncbi.nlm.nih.gov/pubmed/30132722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR15099.1
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