Yet Another Function of p53—The Switch That Determines Whether Radiation-Induced Autophagy Will Be Cytoprotective or Nonprotective: Implications for Autophagy Inhibition as a Therapeutic Strategy

The influence of autophagy inhibition on radiation sensitivity was studied in human breast, head and neck, and non–small cell lung cancer cell lines, in cell lines that were either wild type or mutant/null in p53, and in cells where p53 was inducible or silenced. Whereas ionizing radiation promoted...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Chakradeo, Shweta, Sharma, Khushboo, Alhaddad, Aisha, Bakhshwin, Duaa, Le, Ngoc, Harada, Hisashi, Nakajima, Wataru, Yeudall, W. Andrew, Torti, Suzy V., Torti, Frank M., Gewirtz, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407732/
https://ncbi.nlm.nih.gov/pubmed/25667224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095273
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