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Yet Another Function of p53—The Switch That Determines Whether Radiation-Induced Autophagy Will Be Cytoprotective or Nonprotective: Implications for Autophagy Inhibition as a Therapeutic Strategy

The influence of autophagy inhibition on radiation sensitivity was studied in human breast, head and neck, and non–small cell lung cancer cell lines, in cell lines that were either wild type or mutant/null in p53, and in cells where p53 was inducible or silenced. Whereas ionizing radiation promoted...

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Detaylı Bibliyografya
Yayımlandı:Mol Pharmacol
Asıl Yazarlar: Chakradeo, Shweta, Sharma, Khushboo, Alhaddad, Aisha, Bakhshwin, Duaa, Le, Ngoc, Harada, Hisashi, Nakajima, Wataru, Yeudall, W. Andrew, Torti, Suzy V., Torti, Frank M., Gewirtz, David A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407732/
https://ncbi.nlm.nih.gov/pubmed/25667224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095273
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