Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells

Radiotherapy continues to be a primary modality in the treatment of cancer. DNA damage induced by radiation can promote apoptosis as well as both autophagy and senescence, where autophagy and senescence can theoretically function to prolong tumor survival. A primary aim of this work was to investiga...

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Bibliographic Details
Published in:Radiat Res
Main Authors: Alotaibi, Moureq, Sharma, Khushboo, Saleh, Tareq, Povirk, Lawrence F., Hendrickson, Eric A., Gewirtz, David A.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821451/
https://ncbi.nlm.nih.gov/pubmed/26934368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR14202.1
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