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Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML
Acute myeloid leukemia (AML) can display de novo or acquired resistance to cytosine arabinoside (Ara-C), a primary component of induction chemotherapy. To identify genes capable of independently imposing Ara-C resistance, we applied a genome-wide CRISPR library to human U937 cells and exposed to the...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5093682/ https://ncbi.nlm.nih.gov/pubmed/27808171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36199 |
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