A Novel Hypoxia-Selective Epigenetic Agent RRx-001 Triggers Apoptosis and Overcomes Drug Resistance in Multiple Myeloma Cells

The hypoxic bone-marrow (BM) microenvironment confers growth/survival and drug-resistance in multiple myeloma (MM) cells. Novel therapies targeting the MM cell in its hypoxic-BM milieu may overcome drug resistance. Recent studies led to the development of a novel molecule RRx-001 with hypoxia-select...

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Publicado en:Leukemia
Autores principales: Das, Deepika Sharma, Ray, Arghya, Das, Abhishek, Song, Yan, Oronsky, Bryan, Richardson, Paul, Scicinski, Jan, Chauhan, Dharminder, Anderson, Kenneth C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093055/
https://ncbi.nlm.nih.gov/pubmed/27118403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.96
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